1. Antipyretic and analgesic drugs

Alcohol can cause a large secretion of serum gastrin, and antipyretic and analgesic drugs such as aspirin and acetaminophen can also increase the secretion of serum gastrin. The combination of the two may lead to a significant increase in gastrin secretion concentration and a large amount of gastric acid secretion, resulting in the destruction of the gastric mucosal barrier, damage to submucosal blood vessels, and a risk of gastric bleeding.

It is worth mentioning that some healthy people may experience severe headaches after drinking alcohol. If they take painkillers on their own, it can also easily trigger gastrointestinal bleeding.

2. Sedatives and sleeping pills

Ethanol has an inhibitory effect on the central nervous system, and its effect is proportional to the amount of alcohol consumed. Taking central nervous system depressants such as phenobarbital, chlorpromazine, and chloral hydrate after drinking can cause deep inhibition of the central nervous system. Mild cases can lead to drowsiness, severe cases can cause coma, and even death due to central nervous system paralysis.

3. Antiallergic drugs

Such as diphenhydramine, chlorpheniramine, dechlorohydroxyzine, cyproheptadine, etc. The consequences of taking these drugs with alcohol are similar to those of sedatives and hypnotics.

4. Antibacterial drugs

Medications such as cephalosporins, furosemide, metronidazole, etc., alcohol consumption can inhibit the metabolism of ethanol, causing a "disulfiram like reaction", resulting in a series of symptoms such as headache, dizziness, nausea, vomiting, palpitations, chest tightness, difficulty breathing, and blood pressure drop.

5. Hypoglycemic drugs

Alcohol has the effect of inhibiting sugar absorption. Taking hypoglycemic drugs such as glibenclamide, metformin, or injecting insulin after drinking alcohol can cause rapid drops in blood sugar, leading to hypoglycemic reactions such as dizziness, palpitations, cold sweats, and hand tremors. In severe cases, it can cause hypoglycemic coma. If not rescued in time, it can be life-threatening.

It is worth noting that this symptom of hypoglycemia is often masked by drunkenness reactions and is difficult to distinguish from drunkenness, leading to severe and persistent hypoglycemia, irreversible damage to brain tissue, and even death.

During the use of sulfonylurea hypoglycemic drugs, ethanol acts as a drug enzyme inducer, promoting the metabolism of sulfonylurea drugs and significantly shortening their half-life, thereby weakening their hypoglycemic effects.

In addition, taking metformin and other biguanide hypoglycemic drugs after drinking alcohol may also cause lactic acidosis.

6. Antiepileptic drugs

Drinking alcohol during medication, such as phenytoin sodium, can reduce efficacy and even induce seizures.

7. Antiangina drugs

Vasodilators such as isosorbide dinitrate, nitroglycerin, and nifedipine, when consumed with alcohol, can cause excessive vasodilation, leading to severe headaches, sharp drops in blood pressure, and even shock.

8. Antihypertensive medication

Alcohol has the ability to dilate blood vessels, leading to sympathetic nervous system and vascular motor centers, as well as weaken myocardial contractility. If taking antihypertensive drugs (such as compound nifedipine, hydralazine, nifedipine, Dibazole, furosemide, diuretic acid, etc.) after drinking alcohol, small blood vessels will dilate further, blood volume will decrease further, blood pressure will drop sharply, and postural hypotension or fainting may occur.

9. Hemostatic and anticoagulant drugs

Alcohol can inhibit clotting factors, counteract hemostatic drugs, and greatly weaken the effectiveness of hemostatic drugs. Alcohol can affect the competition of anticoagulants such as coumarin for liver enzymes, thereby enhancing their anticoagulant effect, shortening the half-life of the drug, and affecting its efficacy.

10. Diuretics

Diuretics such as hydrochlorothiazide, furosemide, and spironolactone can lower blood pressure through urination. Once alcohol is consumed, the vasodilatory effect of alcohol can cause low blood pressure, dizziness, and even vertical collapse.

11. Antidepressants

Like imipramine and doxycycline. If alcohol is consumed during medication, it can have a calming effect, thereby reducing the effectiveness of the medication. It can also lead to the deposition of fat in the liver, weaken small intestinal peristalsis, and even cause intestinal paralysis.

12. Anti tuberculosis drugs

The oxidation process of alcohol in the body can generate a large amount of free radicals, and an increase in free radicals can damage liver cells. Isoniazid, rifampicin and other anti tuberculosis drugs can increase the liver toxicity of alcohol, causing jaundice and liver dysfunction.